What question did this study set out to answer?

To identify and characterize new fungal metabolites, specifically furanosteroids and a 4-methylprogesteroid, from Nodulisporium sp.

February 12, 2026Organic & Biomolecular Chemistry0 citations

Discovery of four novel furanosteroids and a new 4-methylprogesteroid from demethoxyviridin pathway-disrupted mutants of Nodulisporium sp. through cultivation time extension

YGYao-Hui Gao XPXiao Pan QWQin-Lian Wang

Key Points

To identify and characterize new fungal metabolites, specifically furanosteroids and a 4-methylprogesteroid, from Nodulisporium sp.
Cultivation of Nodulisporium sp. mutants with extended time periods
Isolation and structural determination of metabolites
Assessment of biological activities related to phosphatidylinositol 3-kinase inhibition
Discovery of four new furanosteroids and one new 4-methylprogesteroid
Confirmatory results indicating significant biological activity of the new compounds
Elucidation of pathways impacted by cultivation time extension leading to enhanced metabolite production

Abstract

Furanosteroids are a structurally distinctive class of fungal metabolites with significant biological activities, particularly well-known as potent phosphatidylinositol 3-kinase inhibitors. Previously, we have elucidated the biosynthetic pathway of demethoxyviridin, one...

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