Design, synthesis, structural characterization, anticancer evaluation, and computational studies of novel quinoline-1,2,3-triazole glycohybrids

Key Points

• The study aims to design and evaluate the anticancer properties of novel quinoline-1,2,3-triazole glycohybrids.
• Synthesis of phenyl-substituted quinoline–1,2,3-triazole glycoconjugates via CuAAC reaction.
• Characterization using spectroscopy and X-ray analysis.
• Structural and electronic features examined through crystal packing, molecular docking, and DFT studies.
• Novel glycohybrids displayed promising anticancer activity.
• Molecular docking highlighted potential interactions with cancer-related targets.
• DFT studies provided insights into electronic properties of the synthesized compounds.