Verbenone-Based Selenophene Derivatives as Potential Anti-cancer Agents: Synthesis and Biological Evaluation in 2D and 3D A549 Cell Models

Key Points

• This research aims to design and evaluate novel verbenone-selenophene derivatives for their anti-cancer properties.
• Rational design of verbenone-selenophene hybrids.
• In vitro evaluation of their antiproliferative activities.
• Testing in both 2D and 3D A549 cell models to assess efficacy.
• Several derivatives exhibited significant antiproliferative effects against A549 cancer cells.
• 3D cell cultures showed enhanced sensitivity compared to 2D models.
• Hybrid compounds demonstrated varying degrees of potency, indicating potential as anti-cancer agents.