Sophora tonkinensis reprograms tumor-associated macrophages to M1-like phenotype and exerts anti-hepatocellular carcinoma effects

Key Points

• The study aims to explore how Sophora tonkinensis affects tumor-associated macrophages and its anti-cancer effects.
• Investigated the effect of Sophora tonkinensis on tumor-associated macrophages (TAMs)
• Analyzed the JAK1/STAT1 signaling pathway
• Assessed antitumor activity in hepatocellular carcinoma models
• Sophora tonkinensis reprograms TAMs to an M1-like phenotype
• Demonstrated significant antitumor activity
• Highlighted the suitability for macrophage-targeted immunotherapy