What question did this study set out to answer?

This research aims to investigate how brain-gut axis-based treatments can help relieve fatigue in Long COVID and ME/CFS.

February 13, 2026Open Access

Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review

Key Points

This research aims to investigate how brain-gut axis-based treatments can help relieve fatigue in Long COVID and ME/CFS.
Systematic review of case-based evidence
Focus on interventions like vagal stimulation
Assessment of neuroinflammation and microbiome balance
Brain-gut interventions may reduce fatigue in affected populations
Vagal stimulation shows promise for severe symptoms
Need for larger studies to optimize treatment strategies

Abstract

Brain-gut axis-based interventions may alleviate fatigue in ME/CFS and Long COVID by potentially modulating neuroinflammation, restoring microbiome balance, and improving epithelial barrier function. EA-based vagal stimulation represents a feasible option for patients with severe or treatment-resistant symptoms. Larger mechanistic studies and rigorously designed RCTs are needed to establish therapeutic targets and optimize intervention strategies.

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