TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor

Key Points

• The aim is to investigate how TAZ regulates gluconeogenesis and tumor growth in hepatocellular carcinoma via its interaction with the glucocorticoid receptor.
• Analyzed the effects of TAZ knockdown on tumor progression and gluconeogenesis.
• Examined TAZ's interaction with the glucocorticoid receptor (GR).
• Assessed transcriptional activity of GR on gluconeogenic gene promoters.
• TAZ knockdown significantly reduced tumor progression.
• TAZ enhanced gluconeogenesis and promoted tumor growth.
• TAZ suppresses GR's transcriptional activity on gluconeogenic genes.