What question did this study set out to answer?

To examine how cerebral autoregulation changes post-aneurysmal subarachnoid hemorrhage using the pressure reactivity index.

February 13, 2026Neurology and Therapy0 citationsOpen Access

Temporal Dynamics of Cerebral Autoregulation after Aneurysmal Subarachnoid Hemorrhage: Insights from Pressure Reactivity Index and Non-injured Controls

UHUe-Cheung Ho NWNathan Wei LKLu-Ting Kuo

Key Points

To examine how cerebral autoregulation changes post-aneurysmal subarachnoid hemorrhage using the pressure reactivity index.
Utilized the pressure reactivity index (LPRx) as a marker for autoregulation integrity.
Compared cerebral autoregulation in patients with aSAH and non-injured controls.
Analyzed the relationship between LPRx and intracranial pressure (ICP) dynamics.
LPRx consistently elevated in aSAH patients compared to controls.
Non-linear relationship observed between LPRx and ICP, suggesting complex autoregulatory responses.
Conventional treatment approaches did not effectively restore autoregulation, emphasizing a need for LPRx-informed strategies.

Abstract

The LPRx is a feasible and physiologically relevant marker of autoregulatory integrity in aSAH. Its consistent elevation and non-linearity with ICP highlight its potential for individualized ICP management. Conventional interventions do not significantly restore autoregulation, highlighting the need for LPRx-informed treatment strategies.

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