Aging is associated with progressive cardiomyocyte hypertrophy, degeneration of myofibrils, lipofuscin accumulation, and increased interstitial fibrosis leading to reduced myocardial elasticity and stiffness.
Aging is associated with progressive histological remodeling of cardiac muscle tissue, including cardiomyocyte hypertrophy and interstitial fibrosis, which contribute to myocardial stiffness and reduced elasticity.
Age-related changes in cardiac muscle tissue represent an important morphological basis for the development of cardiovascular diseases in the elderly. This study aims to analyze histological alterations of myocardial tissue associated with aging, with particular attention to structural, cellular, and interstitial modifications. Histological examination revealed progressive hypertrophy of cardiomyocytes, a reduction in the regenerative capacity of muscle fibers, and an increase in connective tissue components with advancing age. Additionally, age-related degeneration of myofibrils, accumulation of lipofuscin granules, and changes in nuclear morphology were observed.
Jumayeva et al. (Wed,) conducted a other in Individuals across different age groups including young adults, middle-aged individuals, and elderly subjects assessed for age-related histological changes in cardiac muscle tissue. Aging is associated with progressive cardiomyocyte hypertrophy, degeneration of myofibrils, lipofuscin accumulation, and increased interstitial fibrosis leading to reduced myocardial elasticity and stiffness.