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The research examines how BMPR2 signaling influences mitochondrial Ca2+ transport through modulation of a TAK1 splice variant.

February 14, 2026Cell Communication and Signaling0 citationsOpen Access

Bone morphogenetic protein receptor 2 signaling mediates mitochondrial Ca2+ transport through its regulation of TAK1 splice variant

ATAshley Toussaint MSManohar Singh HCHellen Chiou

Key Points

The research examines how BMPR2 signaling influences mitochondrial Ca2+ transport through modulation of a TAK1 splice variant.
Investigation of BMPR2 signaling pathways
Analysis of mitochondrial Ca2+ transport mechanism
Examination of TAK1 splice variant regulation
BMPR2 signaling regulates the expression of the TAK1 splice variant
Mitochondrial Ca2+ transport is dependent on the MCU
Aberrant BMPR2 signaling may affect cell survival and metabolic function

Abstract

These studies reveal that BMPR2 signaling regulates TAK1-d splice variant to mediate mitochondrial Ca2+ transport, which is dependent on the MCU. Our studies suggest that BMPR2 signaling utilizes mtCa2+ transport to regulate both mitochondrial bioenergetics and/or cell survival. Our studies provide novel insight into how aberrant BMPR2 signaling is pathogenic and suggests that the response could vary depending on the cell type.

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