Computational modeling and experimental validation for developed non-hormonal in-situ reversible cervical contraceptive plugs

Key Points

• This research aims to develop and validate a non-hormonal, reversible cervical contraceptive plug.
• Conducted ex-vivo studies to assess sperm immobilisation and morphological changes.
• Performed in-vivo studies to evaluate contraceptive effectiveness and safety.
• Conducted stability studies to analyze formulation properties.
• Achieved 100% contraception in in-vivo studies without mucosal irritation.
• Confirmed that fertility was restored post-study.
• Indicated robust stability of the formulation properties.

Abstract