A high triglyceride-glucose index (≥8.79) was inversely associated with the prevalence of atrial fibrillation compared to a low index in patients with hypertrophic cardiomyopathy (OR 0.680).
Cross-Sectional (n=1,284)
No
Is a higher triglyceride-glucose index associated with a reduced prevalence of atrial fibrillation in patients with hypertrophic cardiomyopathy?
1,284 consecutive inpatients with a primary or secondary diagnosis of hypertrophic cardiomyopathy (maximal LV wall thickness ≥15 mm in the absence of other causes), admitted to Beijing Anzhen Hospital.
Higher Triglyceride-Glucose (TyG) index (evaluated as a continuous variable and as a categorical variable with high TyG index ≥8.79)
Lower Triglyceride-Glucose (TyG) index (<8.79)
Prevalence of atrial fibrillation (AF)hard clinical
In patients with hypertrophic cardiomyopathy, a higher triglyceride-glucose index is independently associated with a lower prevalence of atrial fibrillation and less severe structural remodeling.
Effect estimate: OR 0.680 (95% CI 0.495-0.933)
Absolute Event Rate: 16.7% vs 27.1%
p-value: p=0.017
In conclusion, our study demonstrates that a higher TyG index is inversely associated with key adverse features in HCM, including LAD, and the prevalence of AF and moderate-to-severe MR. Further investigations are warranted to elucidate the mechanisms underlying these associations and their impact on the long-term prognosis of HCM.
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Shengwei Wang
Beijing Anzhen Hospital
Ke Zhang
Chinese Academy of Medical Sciences & Peking Union Medical College
Changwei Ren
Capital Medical University
European journal of medical research
Beijing Anzhen Hospital
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Wang et al. (Thu,) conducted a cross-sectional in Hypertrophic cardiomyopathy (HCM) (n=1,284). High Triglyceride-glucose (TyG) index (≥8.79) vs. Low TyG index (<8.79) was evaluated on Prevalence of atrial fibrillation (OR 0.680, 95% CI 0.495-0.933, p=0.017). A high triglyceride-glucose index (≥8.79) was inversely associated with the prevalence of atrial fibrillation compared to a low index in patients with hypertrophic cardiomyopathy (OR 0.680).
synapsesocial.com/papers/699010ce2ccff479cfe56f5e — DOI: https://doi.org/10.1186/s40001-026-04035-2