Assessment of a High-resolution HPLC System to Quantify HbE for α 0 -Thalassemia Diagnosis in HbE Heterozygotes

Key Points

• To evaluate the effectiveness of a high-resolution HPLC system in quantifying HbE for α⁰-thalassemia diagnosis.
• Utilized a high-resolution HPLC system for HbE quantification
• Conducted analysis specifically in HbE heterozygotes
• Assessed diagnostic capability without evaluating HbA₂
• Demonstrated precise quantification of HbE levels
• Proposed a robust method for α⁰-thalassemia diagnosis
• Highlighted the utility of HPLC for screening purposes

Abstract