Systematic review of the use of cyanoacrylate glue in addition to standard securement for neonatal central venous catheter fixation

Background: Epicutaneous-Caval Catheters (ECCs) and/or neonatal Peripherally Inserted Central Catheters (n-PICCs) are commonly used in neonatal care, but securing these catheters remains a challenge. Recent studies have suggested that cyanoacrylate glue might offer a safer, more reliable alternative to traditional suture fixation. This study aimed to evaluate the efficacy and safety of cyanoacrylate glue as an adjunct to standard catheter securement methods in reducing complications such as dislodgement, catheter-related bloodstream infections (CRBSI), and hemorrhage. Methods: A systematic review of randomized clinical trials was conducted according to PRISMA 2020 guidelines. Databases including MEDLINE/PubMed, CENTRAL, and Embase were searched for studies involving neonatal central venous catheters secured with cyanoacrylate glue. Trials in English, Spanish, or Portuguese were considered, excluding studies with arterial or umbilical catheters, animal studies, and incomplete trials. Results: Twelve studies involving 3076 central venous catheters were included. Results showed that cyanoacrylate glue significantly reduced catheter-related complications, including dislodgement, infection, and thrombosis, compared to traditional securement methods. Conclusions: Cyanoacrylate glue appears to be an effective and safe alternative for securing neonatal central venous catheters. Further research is needed to standardize its use in clinical practice.