Maintenance management after dupilumab discontinuation in moderate-to-severe atopic dermatitis: a comparative study of proactive intermittent tacrolimus and reactive rescue therapy

Key Points

• This research aims to compare proactive intermittent tacrolimus with reactive rescue therapy following dupilumab discontinuation in patients with moderate-to-severe atopic dermatitis.
• Comparative study design
• Assessment of proactive intermittent tacrolimus versus reactive rescue therapy
• Evaluation of flare risk and steroid burden
• Proactive tacrolimus significantly reduces flare risk compared to reactive therapy
• Lower steroid usage observed in patients on proactive tacrolimus
• Improved overall outcomes reported with proactive treatment strategy