Near-Infrared Fluorescence Imaging of Vimentin Dynamic Enables Evaluation of Stroke Therapy in Live Mice

Key Points

• This research aims to evaluate a new imaging technique for observing vimentin dynamics in stroke models.
• Developed a new near-infrared fluorescent probe called Vim-NIG.
• Visualized vimentin dynamics in live stroke mice brains.
• Assessed spatiotemporal changes in vimentin during stroke therapy.
• Vim-NIG successfully visualized vimentin in real-time within the brain tissue.
• Demonstrated distinct spatiotemporal patterns of vimentin associated with stroke therapy.