Multimodal radiosensitization by Hafnium Oxide Nanoparticles and HDAC inhibitors: mechanistic insights

Key Points

• The aim is to explore how hafnium oxide nanoparticles and HDAC inhibitors work together to enhance radiosensitivity in cancer cells.
• Utilized in vitro models to assess the effects of hafnium oxide nanoparticles and HDAC inhibitors during radiation exposure.
• Measured cell viability and DNA damage to evaluate radiosensitization effects.
• Conducted mechanistic studies to understand how these agents enhance radiation effects.
• Hafnium oxide nanoparticles significantly increased the radiosensitivity of cancer cells.
• Combined treatment with HDAC inhibitors further enhanced this effect.
• Mechanistic insights revealed increased DNA damage and altered cellular responses to radiation.