Sequential 3 + 2 Annulation/Intramolecular Transesterification of o -Hydroxyaryl Azomethines and Conjugated Dienes: Access to Chromeno4,3- b pyrrolidines

Key Points

• To explore a new cyclization reaction that efficiently constructs chromeno[4,3-b]pyrrolidine derivatives using o-hydroxyaryl azomethines and conjugated dienes.
• Conducted a domino cyclization reaction of o-hydroxyaryl azomethines with electron-deficient conjugated dienes.
• Investigated the chemoselectivity and substrate scope of the reaction.
• Demonstrated the scalability of the reaction under standard conditions.
• The method successfully produces chromeno[4,3-b]pyrrolidine derivatives with excellent chemoselectivity.
• The reaction is effective across a broad range of substrates.
• Reaction parameters allow for scaling up to gram quantities.