External evaluation confirmed the pediatric PopPK caffeine model's applicability in critically ill neonates with heart disease, supporting pragmatic platform trials.
Pragmatic platform trials can successfully be used for pediatric pharmacokinetic model development and evaluation, specifically for caffeine in critically ill neonates with heart disease.
Absolute Event Rate: 0% vs 0%
External evaluation of a pediatric PopPK model using data from a pragmatic platform trial was successful. Our external evaluation supports broader adoption of pragmatic platform trials for pediatric model development and evaluation. These studies can inform starting doses for future trials, which cannot necessarily be extrapolated from other populations due to variability in drug disposition.
Hallock et al. (Sun,) reported a other. External evaluation confirmed the pediatric PopPK caffeine model's applicability in critically ill neonates with heart disease, supporting pragmatic platform trials.