Ultrawide-field swept-source optical coherence tomography angiography reveals systemic vascular biomarkers in systemic lupus erythematosus: clinical associations with disease activity.

Key Points

• To investigate the potential of ultrawide-field swept-source optical coherence tomography angiography (SS-OCTA) in identifying vascular changes associated with systemic lupus erythematosus (SLE).
• Utilized ultrawide-field SS-OCTA for retinal and choroidal imaging.
• Analyzed microvascular remodeling in SLE patients.
• Correlated MLCV density with disease activity and hydroxychloroquine (HCQ) exposure.
• Identified distinct microvascular remodeling in retinal and choroidal regions of SLE patients.
• Demonstrated that MLCV density correlates with disease progression.
• Supported the utility of SS-OCTA for non-invasive monitoring of vascular changes in SLE.