What type of study is this?

This is a Case-Control Study study.

February 16, 2026Cutaneous and Ocular Toxicology0 citations

Investigating the role of serum human beta defensin-2 in psoriasis and psoriatic arthritis: a case-control study on hBD-2 and CRP, ESR

NKNecip Enis Kaya GKGökçe Işıl Kurmuş AÖAli Erhan Özdemirel

Key Points

To investigate the levels of serum human beta defensin-2 in psoriasis and psoriatic arthritis and their relationship with disease activity.
Conducted a case-control study comparing serum hBD-2 levels in patients with psoriasis and psoriatic arthritis (PsA) to healthy controls.
Measured clinical and laboratory disease activity using CRP and ESR.
Serum hBD-2 levels were found to be elevated in patients with psoriasis and PsA.
No correlation was observed between hBD-2 levels and clinical or laboratory measures of disease activity.

Abstract

Although serum hBD-2 is elevated in psoriasis and PsA, it does not correlate with clinical or laboratory disease activity in psoriasis. These findings suggest that hBD-2 may reflect local cutaneous immune activation rather than systemic inflammation.

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