What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

Evaluate the effect of dual antiplatelet therapy pretreatment on outcomes after intravenous thrombolysis for acute ischemic stroke.

February 16, 2026

Dual antiplatelet therapy pretreatment in patients undergoing intravenous thrombolysis for acute ischemic stroke: a systematic review and meta-analysis of 296,854 patients

Key Points

Evaluate the effect of dual antiplatelet therapy pretreatment on outcomes after intravenous thrombolysis for acute ischemic stroke.
Systematic review of studies including 296,854 patients
Assessment of functional outcomes and mortality
Analysis of risks associated with sICH defined by NINDS criteria
Prestroke DAPT was not linked to favorable functional outcomes
No reduction in mortality observed
Associated with a 1% absolute risk increase in sICH

Abstract

Prestroke DAPT was not associated with favorable functional outcome or reduced mortality after IVT and was associated with a higher risk of sICH when defined by NINDS criteria, with a 1% absolute risk increase.

Dual antiplatelet therapy pretreatment in patients undergoing intravenous thrombolysis for acute ischemic stroke: a systematic review and meta-analysis of 296,854 patients

Key Points

Abstract

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