Carcinoid heart disease (CHD) is a serious and potentially life‑limiting complication of neuroendocrine tumors (NETs), resulting from prolonged systemic exposure to serotonin and other vasoactive substances, leading to fibrotic valvular degeneration. We report the case of a 71‑year‑old woman with metastatic small‑intestinal NET and associated carcinoid syndrome presenting with progressive exertional intolerance. Transthoracic echocardiography revealed severe tricuspid and moderate pulmonary regurgitation with right‑sided ventricular dilation. Cardiac MRI confirmed regurgitation and right‑heart remodeling consistent with CHD.
Kaessner et al. (Thu,) studied this question.