CCL24 recruits CCR3 + TAMs to promote immunosuppression via YAP1 activation and serves as a therapeutic target for Gracillin in colorectal cancer

Key Points

• The research aims to understand how CCL24 contributes to immune regulation in colorectal cancer by activating CCR3 positive TAMs.
• Assessed the role of CCL24 in the tumor microenvironment.
• Investigated the recruitment of CCR3 positive TAMs.
• Analyzed the activation of YAP1 as a mechanism of immunosuppression.
• CCL24 effectively recruits CCR3 positive TAMs in the tumor area.
• YAP1 activation contributes to the immunosuppressive environment.
• Gracillin shows potential as a therapeutic agent targeting this pathway.