Abstract Background and Objectives The Vel antigen is clinically significant and its alloantibody is involved in haemolytic transfusion reactions. This antigen has a high prevalence in the population. The Vel‐negative phenotype is the result of a homozygous deletion in the SMIM1 gene (c. 64₈0del) and hinders the expression of the SMIM1 protein. Materials and Methods A total of 17, 472 blood donor samples from the Center for Hematology and Hemotherapy of Santa Catarina State were genotyped targeting the 17‐nucleotide (c. 64₈0del) deletion in the SMIM1 gene. The same method was applied to the siblings of the donors identified as Vel‐negative. Results The frequency of the c. 64₈0del17 deletion was 0. 90%, and 0. 03% of the donors were Vel‐negative. In the family study, two individuals were identified as having the homozygous c. 64₈0del. Conclusion These findings underscore the relevance of identifying Vel‐negative donors for enhancing rare donor registries and improving transfusion safety.
Siegel et al. (Sun,) studied this question.