Cooling cocrystallization of acetazolamide & p -aminobenzoic acid in continuous slug flow crystallizer

Key Points

• The research aims to explore the continuous production of acetazolamide and p-aminobenzoic acid cocrystal using cooling cocrystallization.
• Utilized a tubular slug flow crystallizer for continuous processing.
• Mimicked batch cooling crystallization conditions.
• Operated under a specific ratio of 1:1 for acetazolamide and p-aminobenzoic acid.
• Successfully produced the 1:1 cocrystal of acetazolamide and p-aminobenzoic acid continuously.
• Demonstrated effective crystallization dynamics within the slug flow system.