What question did this study set out to answer?

The aim is to explore how 4-PSQ influences redox balance and improves symptoms in Alzheimer's disease.

February 19, 2026Redox Report2 citationsOpen Access

Redox modulation contributes to the antidepressant-like and neuroprotective effects of 7-chloro-4-(phenylselanyl)quinoline in an Alzheimer’s disease model

RORenata L. de Oliveira MPMikaela P. Pinz GVGuilherme T. Voss

Key Points

The aim is to explore how 4-PSQ influences redox balance and improves symptoms in Alzheimer's disease.
Administered 4-PSQ in an Alzheimer's disease model.
Assessed behavioral outcomes related to depression and cognition.
Evaluated biochemical changes associated with Aβ toxicity.
4-PSQ restored redox homeostasis.
4-PSQ reduced neuroinflammatory responses.
4-PSQ improved behavioral outcomes linked to depression.

Abstract

By restoring redox homeostasis and attenuating neuroinflammatory responses, 4-PSQ effectively counteracted behavioral and biochemical disruptions associated with Aβ toxicity. These findings support 4-PSQ as a promising selenium-based therapeutic candidate targeting redox-driven features of AD, including comorbid depression and cognitive decline.

Perguntar à IA

Bookmark

View Full Paper