Palladium-Catalyzed Cascade Double Annulation Reaction to Access Unsymmetrical Di(heteroaryl)methanes

Key Points

• The research aims to develop a method for synthesizing unsymmetrical di(heteroaryl)methanes using palladium-catalyzed reactions.
• Implemented a palladium-catalyzed cascade double annulation reaction.
• Synthesis involved five steps combining non-heteroaryl substrates with furan and indole/isoquinolinone scaffolds.
• Exploration of different reaction conditions to optimize yields.
• Successfully synthesized a variety of unsymmetrical di(heteroaryl)methanes.
• Demonstrated effective integration of furan rings with other heteroaryl groups.
• Achieved high yields in selected reactions, indicating the reaction's reliability.