The findings reveal a "dual-circuit" dysfunction pattern in psoriatic depression: sgACC-DMN hyperconnectivity linked to depressive symptoms, and sgACC-dlPFC (dorsolateral prefrontal cortex) alterations associated with IL-17 elevation. These results establish the sgACC as a neural hub bridging inflammation and mood dysregulation, supporting the "skin-brain axis" hypothesis. The identified FC patterns may serve as biomarkers for targeted interventions in inflammation-related depression.
Liu et al. (Mon,) studied this question.