XFM and HERFD-XAS studies of selenium in tissues and whole blood from mice supplemented with potentially therapeutic selenocompounds

Key Points

• The aim is to examine the bioaccumulation and bioavailability of selenocompounds in mice.
• Utilized X-ray fluorescence microscopy (XFM) and high-energy resolution fluorescence detection X-ray absorption spectroscopy (HERFD-XAS).
• Examined selenium distribution in tissues and whole blood of supplemented mice.
• Analyzed differences in the utilization of various therapeutic selenocompounds.
• Observed significant bioaccumulation of selenium in blood and tissues.
• Detected marked differences in bioavailability among different selenocompounds.
• Supported the hypothesis of in vivo reduction of SeN in mice.