Ceramides are essential lipid molecules that make skin strong, smooth, and healthy in both males and females by maintaining skin texture, hydration, and barrier integrity. They are essential for maintaining healthy, smooth, and resilient skin. Maintaining hydration and an intact barrier function is crucial for skin health to support overall dermal integrity, guard against environmental stresses and prevent water loss. Disruptions in these aspects can lead to dryness, irritation, and increased susceptibility to dermatological conditions. This study aimed to assess the safety and efficacy of a novel moisturizing gel formulation in enhancing skin moisturization and strengthening the water barrier function compared to an untreated control in healthy female volunteer with dry skin on the forearms. In comparison to an untreated control site, this study assessed the safety and effectiveness of a ceramide-based moisturizing gel containing CeraSurge Ultra in improving skin moisturization and barrier function in 33 healthy Indian females (aged 18–40) with dry forearm skin. Over the course of 72 hours, a single application to a chosen forearm site was evaluated using corneometry (skin hydration), tewametry (trans-epidermal water loss, TEWL), dermatological examination, and subject self-evaluation. The findings contribute to understanding how targeted skincare formulations can optimize skin physiology, offering potential benefits for daily skincare routines and therapeutic applications in managing dry skin conditions. This research underscores the importance of evidence-based skincare products in promoting long-term skin health and resilience.
Dr. Geetanjali Shetty1, Rushabh Dharamshi2, Poorna Pai3, Drashti Shah4, Kartiki Jadhav5, Dr. Shalmali Karmarkar6, Priyanka Sharma7, Aditi Vichare8* (Mon,) studied this question.