Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency

Key Points

• To evaluate the effectiveness of hematopoietic cell transplantation from an asymptomatic carrier donor in treating CD40L deficiency.
• Conducted allogeneic hematopoietic cell transplant using a carrier donor.
• Assessed CD40L expression levels post-transplantation.
• Evaluated thymopoiesis and T cell diversity outcomes.
• Analyzed functional T and B cell interactions.
• Achieved 32% CD40L expression post-transplant.
• Observed recovery of thymopoiesis.
• Noted normal T cell diversity.
• Demonstrated functional outcomes in T and B cell interactions.