What question did this study set out to answer?

To investigate whether the timing of CAR T-cell infusion affects patient outcomes in large B-cell lymphoma.

February 19, 2026

Time of infusion does not significantly impact outcomes following CAR T-cell therapy in large B-cell lymphoma

MDMark R. DowlingThe Royal Melbourne Hospital ECEdward R. Scheffer CliffBrigham and Women's Hospital AJAnthony Cole Jeffrey

Key Points

To investigate whether the timing of CAR T-cell infusion affects patient outcomes in large B-cell lymphoma.
Conducted a retrospective analysis of 584 patients
Examined outcomes after CAR T-cell therapy across six Australian centres
Adjusted for confounding variables to assess the impact of infusion timing
Found no significant association between infusion timing and patient outcomes
Results indicate minimal influence of chronobiology on therapeutic effectiveness

Abstract

In this retrospective analysis of 584 patients who received CAR T-cell therapy for LBCL at six Australian centres we found no association between time of infusion and outcome, accounting for confounders, suggesting minimal clinical impact of chronobiology in this setting.

AI से पूछें

Bookmark

View Full Paper