The emerging role of complement inhibitory approaches in the treatment of acute sickle cell disease complications

Key Points

• This research aims to explore the efficacy and safety of complement inhibition in treating complications of sickle cell disease.
• Review of preclinical and clinical data regarding complement and sickle cell disease
• Investigation of proximal and distal complement inhibitors
• Assessment of the potential for innovative therapies
• New insights into the role of complement in sickle cell disease complications
• Identified potential for complement inhibitors to pave the way for future treatments
• Emphasized the need for thorough investigation of efficacy and safety