To investigate the combined effects of magnesium and apigenin on sleep in mice and the underlying mechanisms.
Used normal and insomnia mouse models to evaluate sleep patterns.
Administered magnesium and apigenin combination to assess sleep improvements.
Monitored neuroinflammation and microglial activation levels as potential mechanisms.
Combination treatment significantly improved sleep duration and quality in both mouse models.
Reduced levels of neuroinflammation and microglial activation were observed after treatment.
Abstract
A novel magnesium and apigenin combination improves sleep by suppressing neuroinflammation and microglial activation, offering a new nutraceutical strategy.