HOTAIR promotes the progression of B-cell acute lymphoblastic leukemia by regulating the miR-326/IGF-1R axis and activating the PI3K/AKT signaling pathway

Key Points

• The aim is to explore how HOTAIR influences B-cell acute lymphoblastic leukemia through specific molecular mechanisms.
• Investigated the relationship between HOTAIR and the miR-326/IGF-1R axis.
• Analyzed the role of PI3K/AKT signaling pathway activation.
• Assessed potential therapeutic targets related to HOTAIR.
• HOTAIR significantly promotes the progression of B-ALL.
• Activation of the PI3K/AKT pathway is linked to HOTAIR's influence.
• Regulation of the miR-326/IGF-1R axis is crucial for this process.