What does this research mean for the field?

The CoGEF method is an outdated and questionable technique that should not be used in mechanophore design. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

The commentary critiques the CoGEF method for mechanophore design and advocates for the Newton trajectory method.

February 19, 2026Open Access

Commentary on “A systematic workflow for mechanophore design” in MRS Communications

Key Points

The commentary critiques the CoGEF method for mechanophore design and advocates for the Newton trajectory method.
Evaluation of the CoGEF method's reliability
Comparison with the Newton trajectory method
Discussion of implications for mechanophore design
The CoGEF method is questioned due to its outdated techniques
The Newton trajectory method is recommended as a more reliable alternative

Abstract

Abstract We reject the usage of a very old, questionable method, the CoGEF (Constrained Geometries simulated External Force) method. It was named originally distinguished coordinate method. It is meanwhile replaced by the Newton trajectory method. Graphical abstract

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Cite This Study

Quapp et al. (Tue,) studied this question.

synapsesocial.com/papers/6996a8d4ecb39a600b3eff1e https://doi.org/https://doi.org/10.1557/s43579-026-00924-z

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