Spirochromanone Cst-17 as a potent microtubule destabilizing agent showing anticancer effects in HeLa cells by binding to tubulin

Key Points

• This research investigates the effects of spirochromanone Cst-17 on HeLa cancer cells, focusing on its role as a microtubule destabilizing agent.
• Examined the binding of Cst-17 to tubulin
• Analyzed cell cycle arrest in HeLa cells
• Assessed apoptosis levels in treated cells
• Cst-17 effectively binds to tubulin, disrupting microtubule stability
• HeLa cells exhibited significant cell cycle arrest at the G2/M phase
• Increased apoptosis was observed in Cst-17 treated HeLa cells