Higher siMS scores were associated with significantly higher body mass (83.0 vs 66.1 kg, p<0.001), BMI (27.7 vs 22.7 kg/m², p<0.001), waist circumference (86.4 vs 71.9 cm, p<0.001), central systolic blood pressure (114.1 vs 103.0 mmHg, p<0.001), and lower HRV metrics (pNN50 21.3% vs 38.2%, p<0.001) compared to lower siMS scores, reflecting increased early cardiometabolic burden in a young adult cohort.
Cross-Sectional (n=51)
No
Does a high siMS score reflect increased cardiometabolic burden (adverse hemodynamics and HRV) in healthy young adults compared to a low siMS score?
Higher siMS scores in healthy young adults are associated with adverse hemodynamic and autonomic profiles, suggesting its utility as an early marker of cardiometabolic risk before overt metabolic syndrome develops.
Abstract Purpose Metabolic Syndrome (MetS) increases cardiovascular disease risk, yet early identification of pre-MetS remains challenging. The Simple Method for Quantifying MetS (siMS) score offers potential for detecting cardiometabolic burden in younger and middle-aged, relatively healthy populations. Methods We stratified 51 healthy adults (aged 18–60 years) into Low siMS (LMS, siMS 50 msec, pNN50; high-frequency power), microvascular reactivity (near-infrared spectroscopy vascular occlusion test), blood glucose and lipid profiles, and dietary intake were assessed using established protocols. Results The HMS group exhibited significantly higher body mass, body mass index (BMI), waist and hip circumferences, fat mass, visceral fat, central and peripheral BP, MAP, and augmentation index adjusted to 75 bpm (all p ≤ 0.004), alongside lower HRV metrics (pNN50, high-frequency power, low-frequency power, and total power, p ≤ 0.003), indicating increased cardiometabolic burden. No differences were observed in blood glucose, lipids, dietary intakes, or microvascular reactivity. Conclusion These findings suggest that higher siMS scores reflect early cardiometabolic risk through adverse hemodynamic and autonomic profiles, even in the absence of overt MetS, metabolic abnormalities, or detectable microvascular dysfunction. The siMS score may serve as a proactive tool for identifying at-risk individuals, supporting targeted interventions to mitigate long-term cardiometabolic risk.
Kotarsky et al. (Thu,) conducted a cross-sectional in Healthy young to middle-aged adults aged 18-60 years stratified by metabolic syndrome risk using siMS score (n=51). Higher Simple Method for Quantifying Metabolic Syndrome (siMS) score (≥ 2.085) vs. Lower siMS score (< 2.085) was evaluated on Early cardiometabolic risk as measured by anthropometrics, body composition, central and peripheral hemodynamics, and heart rate variability (HRV). Higher siMS scores were associated with significantly higher body mass (83.0 vs 66.1 kg, p<0.001), BMI (27.7 vs 22.7 kg/m², p<0.001), waist circumference (86.4 vs 71.9 cm, p<0.001), central systolic blood pressure (114.1 vs 103.0 mmHg, p<0.001), and lower HRV metrics (pNN50 21.3% vs 38.2%, p<0.001) compared to lower siMS scores, reflecting increased early cardiometabolic burden in a young adult cohort.