What question did this study set out to answer?

To compare B-cell repertoire in salivary glands and peripheral blood of Sjögren’s disease patients and controls.

February 22, 2026

Massively parallel sequencing of B-cell receptors in Sjögren’s disease salivary glands

Key Points

To compare B-cell repertoire in salivary glands and peripheral blood of Sjögren’s disease patients and controls.
Utilized massively parallel sequencing to analyze B-cell receptors.
Collected and compared samples from salivary glands and peripheral blood of patients with Sjögren’s disease and controls.
Evaluated lymphocytic infiltration in salivary glands.
Identified distinct B-cell repertoire in salivary glands compared to peripheral blood.
Found evidence of clonally expanded autoreactive B-cells in Sjögren’s disease patients.
Highlighted potential link between B-cell abnormalities and lymphomas.

Abstract

Background: Sjögren’s disease (SjD) is a chronic autoimmune disease typified by the lymphocytic infiltration of salivary glands (SGs). The SGs are hypothesised to be a reservoir for autoreactive B-cells that clonally expand and transform into lymphomas. We therefore aimed to compare the B-cell repertoire in paired SGs and peripheral blood (PB) from patients with SjD and controls.

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Cite This Study

Lee et al. (Sun,) studied this question.

synapsesocial.com/papers/699a534bfdaf4e3c1268eed8 https://doi.org/https://doi.org/10.1016/j.pathol.2026.01.286

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