Lower health-related quality of life measured by KCCQ-12 SS was an independent predictor of increased all-cause mortality, with a 22% higher hazard per 10-unit decrement in HF patients without atrial fibrillation and an 11% higher hazard in those with atrial fibrillation.
Observational (n=1,199)
Yes
Does a lower health-related quality of life score predict all-cause mortality in patients with heart failure across different ejection fraction subtypes and atrial fibrillation status?
Lower health-related quality of life is an independent predictor of all-cause mortality in heart failure patients, particularly those without atrial fibrillation and with HFpEF or HFrEF.
Effect estimate: HR 1.22 per 10-unit decrement in KCCQ-12 SS for HF patients without AF; HR 1.11 per 10-unit decrement for HF patients with AF (95% CI 95% CI 1.11–1.35 for HF without AF; 95% CI 1.00–1.22 for HF with AF)
p-value: p=<0.001 for HF without AF; 0.04 for HF with AF
HRQoL was higher in patients with AF and HF compared to those without AF. A lower HRQoL score is an independent predictor of all-cause mortality in HF patients, particularly in those without AF (HFpEF and HFrEF subgroups), although associations varied by HF subtype and AF status.
Molenda et al. (Thu,) conducted a observational in Hospitalized and outpatient patients with heart failure across the spectrum of ejection fraction (HFpEF, HFmrEF, HFrEF) with and without atrial fibrillation (n=1,199). Assessment of health-related quality of life using Kansas City Cardiomyopathy Questionnaire-12 Summary Score (KCCQ-12 SS) vs. Patients stratified by presence or absence of AF and HF subtypes; KCCQ-12 SS decrement compared was evaluated on All-cause mortality during follow-up (HR 1.22 per 10-unit decrement in KCCQ-12 SS for HF patients without AF; HR 1.11 per 10-unit decrement for HF patients with AF, 95% CI 95% CI 1.11–1.35 for HF without AF; 95% CI 1.00–1.22 for HF with AF, p=<0.001 for HF without AF; 0.04 for HF with AF). Lower health-related quality of life measured by KCCQ-12 SS was an independent predictor of increased all-cause mortality, with a 22% higher hazard per 10-unit decrement in HF patients without atrial fibrillation and an 11% higher hazard in those with atrial fibrillation.