Novel derivatives of tetrahydrocarbazole as NADPH oxidase 2 and 4 inhibitors: in silico , synthesis, and in vitro evaluation

Key Points

• The research aims to develop and evaluate tetrahydrocarbazole derivatives as inhibitors of NOX2 and NOX4 for managing oxidative stress.
• In silico modeling for structure-activity relationship assessments.
• Synthesis of tetrahydrocarbazole-6-sulfonamides.
• In vitro evaluation of NOX2 and NOX4 inhibition effectiveness.
• Identified ASP5 and ASP20 as significant inhibitors of NOX2 and NOX4.
• Demonstrated potential for reducing oxidative stress in traumatic brain injury models.