In this work, we present the first sequential microwave-electrosynthesis strategy for the efficient and environmentally friendly synthesis of 2-aminoquinazolinones in a one-pot process. The electrochemical approach employs catalytic amounts of NH 4 I and NaCl as a recyclable mediator-electrolyte system, without the need for external oxidants or metal reagents. Furthermore, one-pot synthetic routes starting from isatoic anhydrides or 2-aminobenzonitriles were developed by merging microwave and electrochemical methods, enabling the efficient synthesis of 2-aminoquinazolinones from diverse precursors in 38 examples with yields ranging from 40% to 98%. The process demonstrates high atom economy, good faradaic efficiency, and substantial reductions in solvent use and waste generation compared to conventional protocols. This approach is compatible with a variety of functional groups and is scalable to gram-scale synthesis without loss of efficiency. Moreover, the protocol can be successfully applied to the synthesis of both bioactive compounds and organocatalysts, highlighting its versatility and environmental benefits. Caption: An efficient procedure was developed for the synthesis of 2-aminoquinazolinones by merging electrochemical and microwave-assisted methods in a one-pot manner. • Combine electrochemical and microwave synthesis in a one-pot fashion • 38 derivatives of 2-aminobenquinazolinones, using catalytic amounts of NH 4 I, NaCl • Diverse starting materials, minimize waste production, and improve sustainability • High atom economy (99%), high faradic efficiency (65%), low E-factor (0.6)
Nguyen et al. (Sun,) studied this question.