Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

Key Points

• This research aims to develop and evaluate an injectable hydrogel using cyclic peptides for biomedical applications.
• Developed a cyclic peptide-based hydrogel (cpGel)
• Conducted rheological analyses to assess injectability and elasticity
• Studied supramolecular interactions between cyclic octapeptide nanofibers and nanosilicates
• Demonstrated excellent injectability and elasticity of cpGel
• Confirmed significant self-healing properties under specific conditions
• Showed that supramolecular interactions enhance the physical performance of the hydrogel