Cu(II)-catalyzed Friedel-Crafts reaction of 2-thiopyrimidine derivatives with aldehydes utilizing water as cocatalyst in the presence of surfactant: elucidation the role of water on reaction mechanism and tautomerism

Key Points

• The aim is to explore how water affects the Friedel-Crafts reaction catalyzed by Cu(II) and its role in tautomerism.
• Utilized Cu(II) catalyst in an aqueous medium with surfactant.
• Conducted reactions with 4-amino-6-hydroxy-2-mercatopyrimidine and various aldehydes.
• Investigated the mechanism and effects of water on the reaction.
• Successful catalytic reactions were achieved using Cu(II) in the presence of water.
• The mechanism revealed significant involvement of water in the reaction sequence.
• Tautomerism was noted to be influenced by the aqueous conditions and surfactant.