What question did this study set out to answer?

The aim is to develop a method for the regioselective construction of spiro compounds using Ru(II) as a catalyst.

February 22, 2026European Journal of Organic Chemistry0 citations

Ruthenium(II)‐Catalyzed Oxidative CH Functionalization and Spirocyclization of 4‐Arylquinazolin‐2‐Ones With Alkynols and Alkynoates

Q: What does this research mean for the field?

Ru(II)‐catalyzed oxidative CH activation enables the regioselective construction of 3‐phenyl‐2‐(prop‐1‐en‐2‐yl)‐l’ H ‐spiro[indene‐1,4′quinazolin]‐2′(3′ H )‐one frameworks in high yields. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

SKSangepu KarthikIndian Institute of Chemical Technology CAChidrawar AjayIndian Institute of Chemical Technology TTT. Ravi TejaIndian Institute of Chemical Technology

Key Points

The aim is to develop a method for the regioselective construction of spiro compounds using Ru(II) as a catalyst.
Utilized Ru(II) as a catalyst for C–H activation
Applied oxidative reactions on 4-arylquinazolinones
Combined reactions with propargylic alcohol derivatives
Achieved high yields in constructing spiro[indene-1,4′quinazolin]-2′(3′H)-one frameworks
Demonstrated wide functional group tolerance in the process

Abstract

Ru(II)‐catalyzed oxidative CH activation/annulation of 4‐arylquinazolinones with propargylic alcohol derivatives has been developed for the regioselective construction of 3‐phenyl‐2‐(prop‐1‐en‐2‐yl)‐l’ H ‐spiroindene‐1,4′quinazolin‐2′(3′ H )‐one frameworks in high yields with wide functional group tolerance.

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