Isocoumarin route to the construction of resorcylic acid lactones (RALs): Asymmetric total synthesis of naturally occurring RAL neocosmosin A and isocoumarin containing fusariumin, penicipyran D

Key Points

• This synthesis aims to efficiently produce neocosmocin A using isocoumarin as a starting material.
• Utilized Ag(I) mediated 6-endo-dig cyclization
• Employed a properly substituted isocoumarin framework
• Focused on asymmetric synthesis techniques
• Achieved concise synthesis of neocosmocin A
• Constructed isocoumarin framework successfully
• Demonstrated potential for synthesizing related RALs