Causal links between brain multimodal features (morphometry, metabolomics, networks) and erectile dysfunction: evidence from Mendelian randomization

Key Points

• This research aims to identify brain features that have causal links to erectile dysfunction.
• Utilized Mendelian randomization to assess causal relationships.
• Analyzed morphological, functional connectivity, and metabolic brain features.
• Identified specific relationships between brain features and erectile dysfunction.
• Found four morphological and two functional connectivity relationships with erectile dysfunction.
• Identified nine metabolic causal relationships with erectile dysfunction.
• Provided insights into potential therapeutic targets for treatment of erectile dysfunction.