Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19 F MRI Feasibility (Small 11/2026)

Key Points

• This research aims to develop a novel method for targeted mRNA delivery using ultrasound-responsive nanocarriers.
• Developed nanodroplets that convert to microbubbles under ultrasound activation
• Utilized fluorine-19 MRI for tracking the delivery process
• Focused on localized mRNA delivery to vascular cells
• Demonstrated successful imaging and tracking of nanodroplets in real-time
• Achieved precise control over mRNA delivery in targeted areas
• Revealed strong potential for improving therapeutic delivery methods