A Prospective, Multicenter, Open Label Study Investigating the Implementation of a Standardized Algorithm for Coronary CaLcificatiOn With PlaquE Modification Using UltraSound Guidance to Improve Procedural and Clinical Outcomes (CYCLOPES): Design and Rationale of the CYCLOPES Trial

Key Points

• The study aims to assess the effectiveness of a standardized intravascular ultrasound algorithm for modifying coronary calcification in patients with severe lesions.
• Prospective multicenter, open-label trial design
• Investigating standardized algorithm for intravascular ultrasound calcium modification
• Target population includes patients with moderate-to-severe coronary calcification
• Evaluating procedural and clinical outcomes post-implementation
• Expected improvement in stent delivery and expansion effectiveness
• Potential enhancement of procedural safety and patient outcomes
• Investigation of device efficacy compared to established methods