Phthalimide–4,5-dihydrooxazoline derivatives constitute an important class of heterocyclic hybrid molecules in contemporary medicinal chemistry. The phthalimide nucleus is associated with a wide range of biological activities, while the 4,5-dihydrooxazoline ring offers favorable conformational flexibility and hydrogen-bonding potential, contributing to improved biological performance. Molecular hybridization of these two scaffolds has emerged as a rational strategy to enhance pharmacological potency and selectivity. Recent studies have demonstrated that phthalimide–4,5-dihydrooxazoline derivatives exhibit diverse biological activities, including anticancer, antimicrobial, anti-inflammatory, and central nervous system (CNS) effects, with particular emphasis on anticonvulsant activity. This review provides a comprehensive overview of recent advances in the synthesis, biological evaluation, and structure–activity relationship (SAR) studies of phthalimide–4,5-dihydrooxazoline derivatives and discusses their future prospects as promising therapeutic agents.
Dr. Anju Goyal2 Khushboo Shrimali*1 (Fri,) studied this question.